Thermo Fisher Scientific RPE65 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000
• Publications: View 1 publication

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000
• Publications: View 1 publication

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and shares 88% identity with human sequence.
• Specificity of this antibody: RPE65.

Target Information

RPE65 is a major protein of the retinal pigment epithelium (RPE).
It is essential for the regeneration of rhodopsin in the visual cycle.
Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA).
Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.