Thermo Fisher Scientific RPE65 Polyclonal Antibody
RPE65 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB 및 IHC에 사용 가능. 마우스와 랫트 반응성, 합성 펩타이드 기반 항원 사용. 시각 주기 연구 및 망막 색소 상피 단백질 분석에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
- Publications: View 1 publication
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
- Publications: View 1 publication
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 490–533 of mouse RPE65 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and shares 88% identity with human sequence.
- Specificity of this antibody: RPE65.
Target Information
RPE65 is a major protein of the retinal pigment epithelium (RPE).
It is essential for the regeneration of rhodopsin in the visual cycle.
Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA).
Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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