Thermo Fisher Scientific Phospho-PSD-95 (Tyr236, Tyr240) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of PSD-95 only when phosphorylated at Tyr236/Tyr240.

Target Information

Post Synaptic Density 95 kDa (PSD-95), also known as synapse-associated protein 90 kDa (SAP90), is a membrane-associated protein found in the postsynaptic density of forebrain neurons and certain presynaptic structures in the cerebellum.
PSD-95 contains three PDZ domains, an SH3 domain, and a guanylate kinase homology (GuK) domain. It plays a role in clustering NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.

PSD-95 interacts with other proteins through:

1. C-terminal T/SXV motifs shared by NMDA receptors, β1 adrenergic receptor, some serotonin receptors, and sodium/potassium channel subunits.
2. PDZ domain interactions, such as with neuronal nitric oxide synthase (nNOS), which associates via a pseudo-homotypic PDZ–PDZ interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.