Thermo Fisher Scientific HRAS Monoclonal Antibody (OTI1C2), TrueMAB
HRAS 단백질을 표적하는 Mouse monoclonal antibody로, WB, IHC, ICC/IF에 적합합니다. Human, Mouse, Rat, Dog에 반응하며 고순도 Affinity chromatography로 정제되었습니다. 연구용으로 Ras 신호전달 및 암 관련 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C2 |
| Immunogen | Full length human recombinant protein of human HRAS produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Monomeric G protein Ras acts as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to downstream signaling pathways that lead to distinct cytoplasmic or nuclear events.
Each mammalian cell contains three Ras proto-oncogenes coding for closely related Ras proteins: H-, K-, and N-Ras.
Oncogenic mutations in Ras genes are present in approximately 30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibits apoptosis.
K-Ras mutations are common in pancreatic, colorectal, and non-small-cell lung carcinomas; H-Ras mutations are common in bladder, kidney, and thyroid carcinomas; N-Ras mutations are found in melanoma, hematological malignancies, and hepatocellular carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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