Thermo Fisher Scientific ADAP Recombinant Rabbit Monoclonal Antibody (JE44-80)
ADAP 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC(P), Flow Cytometry에 적합합니다. 인간 시료 반응성이 있으며 HEK293 세포에서 발현되었습니다. Protein A로 정제된 액상 항체로, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE44-80 |
| Immunogen | Synthetic peptide within Human FYB aa 701–750 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848748 |
Product Specific Information
Positive Control: U937, human tonsil tissue, human appendix tissue, human spleen tissue.
Target Information
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion.
TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors.
Recent studies indicate that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell–antigen presenting cell (APC) activation.
At least three isoforms of ADAP are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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