Thermo Fisher Scientific CMG2 Polyclonal Antibody
인간 CMG2(ANTXR2) 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. IHC(P) 검증 완료, 염소 유래 IgG 형식으로 액상 형태로 제공됩니다. -20°C 보관, 연구용으로 사용 가능합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HEGLKLANEQIQK) corresponding to the internal amino acids of ANTXR2 (aa 121–134). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10984987 |
Product Specific Information
- This antibody is predicted to react with bovine and canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
Anthrax toxin receptor 2 (ATR2), also known as capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type I membrane protein containing an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. It binds to the protective antigen (PA) of Bacillus anthracis, facilitating the delivery of edema factor (EF) and lethal factor (LF) into the cytosol.
Mutations in ATR2/CMG2 inhibit binding by the VWA domain and are associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF), both rare stiff-skin syndromes characterized by hyaline deposition in various organs, especially the skin and gingiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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