Thermo Fisher Scientific MLLT10 Polyclonal Antibody
MLLT10 단백질을 인식하는 Thermo Fisher Scientific의 고트 폴리클로날 항체. Western blot에 적합하며 인간 및 설치류 반응성. 합성 펩타이드 면역원으로 제작, 0.5 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1–3 µg/mL
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RLEDTTARFTNAN) corresponding to internal amino acids of MLLT10 (aa 281–293) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10984955 |
Product Specific Information
- Predicted to react with bovine, canine, human, and mouse based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in these translocations is MLL, and MLLT10 is its partner gene in the t(10;11)(p12;q23) translocation.
MLLT10 encodes a 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain.
MLLT10 can also rearrange with the CALM gene in the t(10;11)(p12;q14) translocation, forming chimeric fusion proteins (MLL/AF10, CALM/AF10) that retain the leucine zipper motif.
This motif interacts with GAS41, which associates with INI1, a component of the SWI/SNF chromatin remodeling complex, suggesting that these fusions may interfere with normal gene regulation through chromatin remodeling interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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