Thermo Fisher Scientific ACER3 Polyclonal Antibody
ACER3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 시료에서 검증됨. 액상 형태로 제공되며, -20°C에서 보관. 세라마이드 대사 및 신경세포 기능 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | – |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human PHCA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2555609 |
Target Information
ACER3 is a protein coding gene. It encodes an endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain ceramides (C18:1-, C20:1-, and C20:4-ceramides), dihydroceramides, and phytoceramides into sphingoid bases such as sphingosine and free fatty acids at alkaline pH.
Ceramides, sphingosine, and sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating biological processes including cell proliferation, apoptosis, and differentiation.
ACER3 controls the generation of sphingosine in erythrocytes, influencing sphingosine-1-phosphate levels in plasma, and may play a role in neuronal survival and function through the regulation of ceramide and sphingosine-1-phosphate homeostasis in the brain. It may also modulate the inflammatory response by regulating proinflammatory ceramide levels in immune cells and tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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