Thermo Fisher Scientific Alpha Sarcoglycan Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins—alpha, beta, gamma, and delta—form a complex on the skeletal muscle cell surface membrane.
A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, observed in autosomal recessive muscular dystrophy (sarcoglycanopathy).
In smooth muscle, beta- and delta-sarcoglycans are associated with epsilon-sarcoglycan, a glycoprotein homologous to alpha-sarcoglycan. A complete deficiency in delta-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.