Thermo Fisher Scientific Alpha Sarcoglycan Polyclonal Antibody
Alpha Sarcoglycan 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot과 Immunocytochemistry에 적합합니다. 인간 SGCA 유래 합성 펩타이드로부터 제작되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 근육 세포막 단백질 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human SGCA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555610 |
Target Information
The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins—alpha, beta, gamma, and delta—form a complex on the skeletal muscle cell surface membrane.
A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, observed in autosomal recessive muscular dystrophy (sarcoglycanopathy).
In smooth muscle, beta- and delta-sarcoglycans are associated with epsilon-sarcoglycan, a glycoprotein homologous to alpha-sarcoglycan. A complete deficiency in delta-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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