Thermo Fisher Scientific NFKBIB Polyclonal Antibody, MaxPab
Thermo Fisher Scientific의 NFKBIB Polyclonal Antibody는 인간 IkB beta 단백질을 인식하는 토끼 IgG 항체입니다. Western blot 및 in situ PLA에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- H00004793-D01P
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
in situ PLA (PLA)
- Tested Dilution: 1:1200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | NFKBIB (NP_002494.2, 1–356 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAGVACLGKA ADADEWCDSG LGSLGPDAAA PGGPGLGAEL GPGLSWAPLV FGYVTEDGDT ALHLAVIHQH EPFLDFLLGF SAGTEYMDLQ NDLGQTALHL AAILGETSTV EKLYAAGAGL CVAERRGHTA LHLACRVGAH ACARALLQPR PRRPREAPDT YLAQGPDRTP DTNHTPVALY PDSDLEKEEE ESEEDWKLQL EAENYEGHTP LHVAVIHKDV EMVRLLRDAG ADLDKPEPTC GRSPLHLAVE AQAADVLELL LRAGANPAAR MYGGRTPLGS AMLRPNPILA RLLRAHGAPE PEGEDEKSGP CSSSSDSDSG DEGDEYDDIV VHSSRSQTRL PPTPASKPLP DDPRPV
Target Information
The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with inhibitory IkB proteins. Activation of NF-kB occurs through phosphorylation-induced, proteasome-mediated degradation of IkB. This process involves activation of the IKK complex, composed of IKK alpha, IKK beta (catalytic subunits), and IKK gamma (regulatory subunit). Phosphorylation at Ser177 and Ser181 in IKK beta (Ser176 and Ser180 in IKK alpha) triggers conformational changes leading to kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: H00004793-D01P_IkB_beta_Q15653-1_Rabbit.svg)
(이미지: H00004793-D01P_IkB_beta_Q15653-1_Rabbit_PDP.jpeg)
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