Thermo Fisher Scientific TCTN3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TCTN3. Recombinant protein control fragment (Product #RP-90154). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TCTN3,uniProtId:Q6NUS6-1,ncbiNodeId:9606,antigenRange:176-294,antigenLength:607,antigenImageFileName:PA5-55473_TCTN3_Q6NUS6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55473_TCTN3_Q6NUS6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648345

Product Specific Information

Immunogen sequence: QKVNATNFQA LAAEFGGESF TSTFQTQSPP SFYRAGDPIL TYFPKWSVIS LLRQPAGVGA GGLCAESNPA GFLESKSTTC TRFFKNLASS CTLDSALNAA SYYNFTVLKV PRSMTDPQN

Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 78%.

Target Information

TCTN3 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN3 is not known, it is 58% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.