Thermo Fisher Scientific PARP6 Polyclonal Antibody
Rabbit polyclonal antibody against human PARP6. Validated for IHC (P) and ICC/IF applications. Antigen affinity purified, supplied in PBS with 40% glycerol. Suitable for research use in studying PARP family and DNA damage response.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PARP6. Recombinant protein control fragment (Product # RP-90670) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645218 |
Product Specific Information
Immunogen sequence:
QLHGAAYGKG IYLSPISSIS FGYSGMGKGQ HRMPSKDELV QRYNRMNTIP QTRSIQSRFL QSRNLNCIAL CEVITSKDLQ KHG
Highest antigen sequence identity to orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) comprise a family of 18 proteins with conserved catalytic domains. Among them, PARP-1 (113 kDa) and PARP-2 (62 kDa) are directly activated by DNA strand breaks. Novel PARP members expand the role of poly(ADP-ribosyl)ation in cell proliferation, death, and regulation through shared partners and subcellular localization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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