Thermo Fisher Scientific CRYAA Monoclonal Antibody (OTI2C3), TrueMAB
Human CRYAA 단백질을 인식하는 마우스 단클론 항체로 Western blot 및 IHC(Paraffin)에 적합함. 액상 형태로 제공되며, 고순도 친화 크로마토그래피 정제. 렌즈 단백질 연구 및 스트레스 반응 관련 단백질 분석에 유용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C3 |
| Immunogen | Full length human recombinant protein of human CRYAA produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
Alpha-crystallin is the largest of the crystallins and is composed of two primary gene products—alpha-A and alpha-B.
There are at least five different proteins comprising the beta-crystallins, while the gamma-crystallins are monomeric, with at least five gamma crystallins identified in bovine and rat lens.
Alpha-crystallin comprises 40% of total lens protein composition.
In addition to maintaining the proper refractive index, it also functions in a chaperone-like manner by preventing the formation of aggregates that may lead to cataract formation.
Phosphorylated states of alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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