Thermo Fisher Scientific CCL19 Monoclonal Antibody (3E9)

Applications

• ELISA (ELISA): Tested dilution 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL IKDGCRVPAV VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS

Target Information

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is closely related to CCL21, sharing 32% amino acid sequence homology. CCL19 and CCL21 are primarily expressed by stromal cells in T cell-rich zones of lymph nodes, mediating homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs. They are also involved in T cell priming, activation, and lymphocyte recruitment to inflamed tissues. Both signal via the G protein-coupled receptor CCR7, which is expressed on T cells and mature dendritic cells. Although both ligands bind CCR7 with similar affinity, only CCL19 binding leads to receptor desensitization and internalization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.