Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Thr311) Polyclonal Antibody
Phospho-Estrogen Receptor alpha (Thr311) 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 최적화. 인체 ESR1 유래 펩타이드 기반 면역원 사용. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human ESR1 (Accession P03372), corresponding to amino acid residues around phosphorylated Thr311 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817248 |
Product Specific Information
Antibody detects endogenous levels of Estrogen Receptor alpha only when phosphorylated at Thr311.
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors.
The estrogen receptor is a ligand-activated transcription factor that, upon binding estrogen, undergoes a conformational change enabling dimerization and DNA binding to estrogen response elements (ERE).
ERs regulate gene transcription through coactivator or corepressor recruitment.
Two forms—ER alpha (ESR1) and ER beta (ESR2)—exist, with multiple isoforms of ER alpha (66 kDa, 53 kDa, 47 kDa, 35 kDa).
They are widely expressed and essential for sexual development, reproductive function, and bone health.
ERs are implicated in breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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