Thermo Fisher Scientific ASH2L Monoclonal Antibody (1B4)
Thermo Fisher Scientific의 ASH2L Monoclonal Antibody (1B4)는 인간 ASH2L 단백질을 표적으로 하는 Mouse IgG2b 항체로, Western Blot 및 ELISA에 사용 가능. 비결합형 액상 형태로 제공되며, 연구용으로만 사용됨. -20°C 보관 필요.
- 카탈로그번호
- H00009070-M21A
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B4 |
| Immunogen | ASH2L (NP_004665.1, 424–530 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EITVDEMPPD TAARLGWSQP LGNLQAPLGY DKFSYSWRSK KGTKFHQSIG KHYSSGYGQG DVLGFYINLP EDTETAKSLP DTYKDKALIK FKSYLYFEEK DFVDKAE
Target Information
The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1 (isoform 1), which contains a nuclear localization signal and a PHD finger motif, suggesting that the gene product functions as a transcription regulator.
Predicted molecular weight: 68.7 kDa
Alternative splicing results in possible isoforms at 60 kDa and 56.5 kDa.
Homology:
- 60% with Drosophila ash2
- 90% with mouse ASH2L
Expression:
- Predominantly in adult heart and testis, and fetal lung and liver
- Barely detectable in adult lung, liver, kidney, prostate, and peripheral leukocytes
- Expressed in leukemia cell lines (K562, Hel, Dami) with erythroid and megakaryocytic potential
Functional relevance:
- Involved in hematopoiesis and associated with specific leukemia types
- Suggested interaction with beta-tubulin and beta-catenin
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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