Thermo Fisher Scientific DACH1 Polyclonal Antibody
인간 DACH1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, IHC(P) 및 ICC/IF 실험에 적합. 항원 친화 크로마토그래피로 정제된 고품질 항체이며, PBS/글리세롤 버퍼에 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- PA552968
- 판매단위
- pk
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Thermo Fisher Scientific DACH1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DACH1. Recombinant protein control fragment (Product #RP-89667). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640365 |
Product Specific Information
Immunogen sequence:
PKRTQSVTSP ENSHIMPHSV PGLMSPGIIP PTGLTAAAAA AAAATNAAIA EAMKVKKIKL EAMSNYHASN NQHGADSENG DMNSSVGSSD GSWDKETLPS SPSQGPQASI THPRMPGARS LPLSHPLNHL QQSHLLPNGL ELP
Highest antigen sequence identity to the following orthologs:
- Mouse: 91%
- Rat: 88%
Target Information
Transcription factor involved in regulation of organogenesis. Acts as a regulator of SIX1, SIX6, and possibly SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also involves association with CREBBP. Functions as a corepressor of SIX6 by repressing cyclin-dependent kinase inhibitors such as p27Kip1. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds chromatin DNA via its DACHbox-N domain.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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