Thermo Fisher Scientific Progesterone Receptor (PR) Monoclonal Antibody (16-4)
인체 PR 단백질을 인식하는 마우스 단클론 항체로, IHC(P) 실험에 최적화되어 있습니다. 단백질 A로 정제된 액상 항체이며, 핵 내 발현 확인에 유용합니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16-4 |
| Immunogen | A synthetic peptide of C-terminus of human PR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast Cancer Tissue
- Cellular location: Nucleus
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events related to pregnancy establishment and maintenance.
PR exists as two forms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), generated by alternative translation initiation sites.
- PR-B: Transcriptionally active form responsible for activating genes for endometrial maintenance, pregnancy, and inhibition of ovulation.
- PR-A: Lacks 165 amino acids at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PR forms a multiprotein complex including heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE), leading to activated transcription.
A null mutation in the PGR gene results in pleiotropic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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