Thermo Fisher Scientific CAHM1 Polyclonal Antibody
Thermo Fisher Scientific CAHM1 Polyclonal Antibody는 Mouse 및 Rat 시료에 반응하며, Western Blot과 IHC에 사용 가능. Lyophilized 형태로 제공되며, 장기 보관 시 -20°C에서 안정적. Alzheimer’s disease 관련 CALHM1 단백질 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:1,000–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 250–300 of mouse CAHM1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen shares 97% identity with the rat sequence.
- Specificity of this antibody: CAHM1.
Target Information
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP).
The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca²⁺ concentration and Abeta levels.
While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca²⁺-dependent proteolytic process of APP through controlling the level of cytosolic Ca²⁺.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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