Thermo Fisher Scientific GITR/TNFRSF18 Recombinant Rabbit Monoclonal Antibody (BLR068G)
GITR/TNFRSF18 단백질을 인식하는 토끼 리콤비넌트 단클론 항체. Western blot, IHC, ICC/IF, Flow cytometry, IP에 사용 가능. HEK293 발현 시스템에서 생산되었으며, 고순도 정제 및 4°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100 – 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 – 1:500 |
| Flow Cytometry (Flow) | 0.2 µL per 1 × 10⁶ cells |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR068G |
| Immunogen | Peptide representing a region between residue 191 and the C-terminus (residue 241) of human Tumor necrosis factor receptor superfamily member 18 (GITR). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1000 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 7.8–8.6 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans and is located on chromosome 1p36.33. This receptor belongs to the TNF-receptor superfamily and shows increased expression upon T-cell activation. It plays a key role in maintaining immunological self-tolerance mediated by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice suggest its involvement in regulating CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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