Thermo Fisher Scientific CLU Monoclonal Antibody (OTI2A7), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of plasma proteins.
It inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro).
CLU maintains partially unfolded proteins for refolding by other chaperones such as HSPA8/HSC70.
Secreted isoforms protect cells from apoptosis and complement-mediated cytolysis, while intracellular isoforms regulate ubiquitination and proteasomal degradation of target proteins, modulate NF-κB transcriptional activity, and influence apoptosis and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.