Thermo Fisher Scientific N4BP2L2 Polyclonal Antibody
Human N4BP2L2 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:20–1:50 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용, 진단용 불가.
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Thermo Fisher Scientific N4BP2L2 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human N4BP2L2. Recombinant protein control fragment (Product #RP-97966). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644414 |
Product Specific Information
Immunogen sequence:
NSEEENKQKL MTFDHHPLWF YLDIIKATPL NIDGQRYSHC LSFNRLRCSA SLYKNYIPSF VLHNLSSIWK PSFTNKKLFL TFESQTRVGN KLNDAGFISP EILHSHPDTS CSLGVTSD
Highest antigen sequence identity to the following orthologs:
- Mouse: 19%
- Rat: 19%
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation.
N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, likely by ATM or ATR. It is primarily expressed in bone marrow and is dramatically down-regulated after exposure to arsenic compounds, an event that precedes neutropenia.
PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, two proteins implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase (ELA2) cause cyclic haematopoiesis, leading to decreased numbers of circulating neutrophils and increased risk for opportunistic infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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