Thermo Fisher Scientific GEMIN2 Monoclonal Antibody (OTI4C11), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins.
The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and pre-mRNA splicing.
SIP1 interacts directly with SMN and is required for formation of the SMN complex.
A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of SIP1 mRNA in motor neurons showed normal motor axons, while knockdown of SMN mRNA caused abnormal motor axon outgrowth, suggesting SIP1 may have additional roles outside the SMN complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.