Thermo Fisher Scientific Synoviolin Polyclonal Antibody
Rabbit polyclonal antibody against human Synoviolin/HRD1, suitable for Western blot and immunoprecipitation. Recognizes region 567–617 of Synovial Apoptosis Inhibitor 1. Supplied as liquid, unconjugated form, 0.20 mg/mL concentration. For research use ...
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 567 and 617 of Human Synovial Apoptosis Inhibitor 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum.
HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney, and skeletal muscle. Synoviolin/Hrd1, expressed in rheumatoid synovium, is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects.
HRD1 contains one ring-type zinc finger.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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