Thermo Fisher Scientific Synoviolin Polyclonal Antibody
Human Synoviolin(HRD1) 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품이며, 4°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and 600 of Human Synovial Apoptosis Inhibitor 1 (HRD1, UniProt ID: Q86TM6-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- The recommended shelf life for this product is 1 year from date of receipt.
Target Information
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum.
HRD1 is expressed in many tissues and is strongly expressed in brain, pancreas, liver, kidney, and skeletal muscle.
It has been reported that Synoviolin/Hrd1, expressed in rheumatoid synovium, is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects.
HRD1 contains one ring-type zinc finger.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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