Thermo Fisher Scientific HOXB4 Polyclonal Antibody
Human HOXB4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer(40% glycerol, 0.02% sodium azide) 형태로 제공. 줄기세포 및 조혈 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HOXB4. Recombinant protein control fragment (Product # RP-99948) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642524 |
Product Specific Information
- Immunogen sequence: CEAVSSSPPP PPCAQNPLHP SPSHSACKEP VVY
- Highest antigen sequence identity: Mouse - 97%, Rat - 94%
Target Information
HOX homeobox genes play a role in early stem cell function and later stages of hematopoietic differentiation.
HOXB4 is a homeotic selector gene involved in self-renewal of definitive hematopoietic stem cells (HSCs).
Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induces a switch to the definitive HSC phenotype.
Activation of WNT signaling in HSCs increases expression of HOXB4.
Perturbations of HOX gene expression can cause leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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