Thermo Fisher Scientific SETD2 Monoclonal Antibody (OTI3G8), TrueMAB
SETD2 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. 인간 유래 SETD2 단백질(aa 1787–2144)로부터 제작됨. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 완충액에 보관. -20°C에서 보관하며 동결·해동 반복은 피해야 함.
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Applications
- Western Blot (WB): 1:200 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1787–2144 of human SETD2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Histone methyltransferase that specifically trimethylates Lys-36 of histone H3 (H3K36me3) using dimethylated Lys-36 (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex. H3K36me3 also plays an essential role in maintaining heterochromatin by recruiting DNA methyltransferase DNMT3A. Enhanced in intron-containing genes, suggesting coupling of splicing and elongating RNA polymerase recruitment. Required during angiogenesis and may regulate adenovirus 12 E1A gene expression upon infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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