Thermo Fisher Scientific CCL19 Monoclonal Antibody (OTI2A12), TrueMAB
인간 CCL19 단백질을 표적으로 하는 Mouse IgG1 단클론 항체. IHC(P)에서 1:150 희석으로 검증됨. 비결합형 액상 형태이며, PBS/BSA/glycerol 완충액에 보관. -20°C에서 보관하며 동결/해동 반복은 피해야 함. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–98 of human CCL19 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is most closely related to CCL21, sharing 32% amino acid sequence homology. CCL19 and CCL21 are primarily expressed by stromal cells in the T cell-rich zones of lymph nodes, serving as key mediators of homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs. They also play roles in T cell priming, activation, and recruitment of lymphocytes to inflamed tissues. Both proteins signal via the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells. Although both bind CCR7 with the same affinity, only CCL19 binding leads to receptor desensitization and internalization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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