Thermo Fisher Scientific MAST2 Monoclonal Antibody (OTI1C12), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve approximately 1 mg/mL antibody concentration.
• For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
  (Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882)

Target Information

Syntrophin is an adapter protein that binds signaling molecules to the dystrophin-associated protein complex, linking the extracellular matrix to the intracellular cytoskeleton for postsynaptic structure maintenance.
Microtubule-associated serine/threonine-protein kinase 2 (MAST205) is a testis-specific cytoplasmic protein involved in spermatid maturation. It connects the dystrophin/utrophin network with microtubule filaments via Syntrophin and forms a complex with TRAF6 to regulate lipopolysaccharide-induced IL-12 synthesis in macrophages, thereby inhibiting TRAF6 NF-κB activation.
Two isoforms exist due to alternative splicing: isoform 1 (full length) and isoform 2 (lacking residues 327–396 and 1091–1113). Phosphorylation of the N-terminus is required for ubiquitination and subsequent proteasome-mediated degradation of MAST205.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.