Thermo Fisher Scientific IGF2BP3 Polyclonal Antibody
IGF2BP3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 및 생쥐 시료에서 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from N-terminal of human IGF2BP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635213 |
Product Specific Information
This antibody detects endogenous levels of total IGF2BP3 protein.
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family. It is expressed during embryogenesis and in some malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is found in a significantly higher proportion of melanomas than Spitz nevi, and more frequently in metastatic melanomas than in thin melanomas.
IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in regulating the biologic behavior of this tumor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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