Thermo Fisher Scientific Phospho-ATM (Ser1981) Polyclonal Antibody
ATM 단백질의 Ser1981 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot에 최적화된 고순도 항체로 DNA 손상 반응 연구에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공.
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-ATM (Ser1981) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
Species Reactivity
- Human
- Mouse
- Rat
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human ATM around phosphorylation site Ser1981 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2803699 |
Product Specific Information
This polyclonal antibody detects endogenous levels of ATM protein only when phosphorylated at Ser1981.
Purity is >95% by SDS-PAGE.
Target Information
Ataxia-telangiectasia Mutated (ATM) is a member of the PI3/PI4 kinase family. Mutations in ATM cause ataxia-telangiectasia, a rare autosomal recessive disorder characterized by neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
ATM phosphorylates proteins involved in cell cycle regulation, including P53, Mdm2, BRCA1, and SMC1. It plays a key role in repairing double-stranded DNA breaks induced by ionizing radiation.
ATM becomes autophosphorylated and activated upon DNA damage, initiating kinase cascades that regulate cell cycle, apoptosis, and DNA repair. Studies link ATM to apoptosis pathways involving Nbs1 and Chk2 in the E2F1 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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