Thermo Fisher Scientific Phospho-LCK (Ser158) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated LCK (Ser158). Validated for Western blot. Suitable for studying T-cell receptor signaling and LCK-mediated phosphorylation pathways. Supplied as liquid, stored at -20°C.
- 카탈로그번호
- 44842G
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from the region of Lck containing serine 158 (Swiss Protein database accession P06239) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Wet or Dry ice (international) |
| RRID | AB_2533777 |
Target Information
LCK is a member of the Src-family tyrosine kinases essential for signaling through the T-cell receptor (TCR) complex. Upon TCR activation, LCK phosphorylates ITAM motifs in zeta subunits, enabling ZAP70 binding and activation. Activated ZAP70 phosphorylates adaptor LAT to propagate downstream signaling.
Most LCK localizes to the plasma membrane, with a portion associated with the Golgi apparatus contributing to Raf activation during weak TCR stimulation. LCK has N-terminal myristylation and palmitylation sites, a PTK domain, and SH2/SH3 domains mediating protein-protein interactions.
LCK is also involved in apoptosis regulation independent of death receptor pathways. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternative splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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