Thermo Fisher Scientific GM2A Polyclonal Antibody
Rabbit에서 유래한 GM2A 단백항체로, Western blot과 ELISA에 사용 가능. 인간 GM2A의 24-193 아미노산 서열 기반 항원 사용. 마우스 및 랫트 반응성. 액상 형태, PBS/glycerol buffer, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 24–193 of human GM2A (NP_000396.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.64 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855184 |
Product Specific Information
Immunogen sequence:
HLKKPSQLSS FSWDNCDEGK DPAVIRSLTL EPDPIIVPGN VTLSVMGSTS VPLSSPLKVD LVLEKEVAGL WIKIPCTDYI GSCTFEHFCD VLDMLIPTGE PCPEPLRTYG LPCHCPFKEG TYSLPKSEFV VPDLELPSWL TTGNYRIESV LSSSGKRLGC IKIAASLKGI
Target Information
This gene encodes a small glycolipid transport protein that acts as a substrate-specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Together with GM2 ganglioside activator, it catalyzes the degradation of ganglioside GM2 and other molecules containing terminal N-acetyl hexosamines.
Mutations in this gene cause GM2-gangliosidosis type AB (AB variant of Tay-Sachs disease).
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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