Thermo Fisher Scientific Glypican 3 Polyclonal Antibody
Glypican 3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, Flow cytometry, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제 및 안정적인 PBS/glycerol buffer 구성.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 481–580 of human Glypican 3 (GPC3) (NP_004475.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.15 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855182 |
Product Specific Information
Immunogen sequence: GNSQQATPKD NEISTFHN
Target Information
GPC3 is a cell surface proteoglycan that bears heparan sulfate. It may be involved in suppression or modulation of growth in mesodermal tissues and organs, and plays a role in modulating IGF2 interactions with its receptor. Members of the glypican family contain a core protein anchored to the membrane via a GPI linkage, contributing to cell division control, growth regulation, and tumor predisposition.
Deletion mutations in GPC3 cause Simpson-Golabi-Behmel syndrome (SGBS), characterized by pre- and postnatal overgrowth with visceral and skeletal anomalies.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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