Thermo Fisher Scientific CD20 (MS4A1) Monoclonal Antibody (OTI10A5), TrueMAB
CD20 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. WB 및 IHC(P) 적용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS/BSA/glycerol buffer에 보관되며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10A5 |
| Immunogen | Full length human recombinant protein of human MS4A1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight range of 33–37 kDa depending on phosphorylation. It is expressed on mature and most malignant B cells, a subpopulation of T lymphocytes, and follicular dendritic cells. CD20 expression coincides with surface IgM and regulates calcium conductance, cell cycle progression, and B-cell proliferation.
CD20 associates with lipid rafts, and its interaction depends on extracellular triggering and BCR aggregation. Following receptor ligation, CD20 colocalizes with BCR but remains at the cell surface after BCR endocytosis. As CD20 is stably expressed on B-cell malignancies and not internalized after antibody treatment, it serves as a key target for therapeutic B-cell depletion.
Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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