Thermo Fisher Scientific EFHD2 Polyclonal Antibody
EFHD2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 ELISA에 적합하며, Mouse 시료 반응성 확인. 고순도 Affinity Chromatography 정제 및 PBS/glycerol buffer로 안정화. 연구용으로만 사용 가능.
- 카탈로그번호
- PA590128
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–78 of human EFHD2 (NP_0773052) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805930 |
Product Specific Information
- Immunogen sequence: MATDELATKL SRRLQMEGEG GGETPEQPGL NGAAAAAAGA PDEAAEALGS ADCELSAKLL RRADLNQGIG EPQSPSRR
- Positive Samples: Mouse lung
- Cellular Location: Membrane raft
Target Information
EFHD2 (also known as Swiprosin-1 or SWS1) is an EF-hand and coiled-coil-containing adaptor protein involved in lymphocyte physiology. It is highly expressed in CD8+ T cells and immature B cells. EFHD2 acts as a membrane scaffold required for Syk-, SLP-65-, and PLC-γ2-dependent B-cell receptor (BCR)-induced calcium flux. It may regulate BCR-induced immature and primary B-cell apoptosis by controlling BCL2L1 abundance and serves as a negative regulator of the canonical NF-κB-activating pathway.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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