Thermo Fisher Scientific LATS2 Polyclonal Antibody
LATS2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 및 생쥐 시료에 반응하며, 세포 증식과 종양 억제 연구에 유용합니다. 1 mg/mL 농도의 액상 형태로, -20°C에서 보관합니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LATS2 (Accession Q9NRM7), corresponding to amino acid residues S846–W896 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900135 |
Product Specific Information
Antibody detects endogenous levels of total LATS2.
Target Information
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. It interacts with a negative regulator of p53 and functions in a positive feedback loop with p53 that responds to cytoskeleton damage, leading to centrosome and mitotic apparatus dysfunction.
LATS2 plays an essential role in maintaining mitotic fidelity and genomic integrity. It regulates organ size and tumor suppression by restricting proliferation and promoting apoptosis.
The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, with SAV1, phosphorylate and activate LATS1/2, which then phosphorylate and inactivate YAP1 and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its nuclear translocation, thereby regulating genes involved in cell proliferation, death, and migration.
LATS2 negatively regulates the G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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