Thermo Fisher Scientific LATS1/LATS2 Polyclonal Antibody
LATS1/LATS2 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 및 생쥐 시료에 반응합니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 고순도 Affinity chromatography로 정제된 1 mg/mL 액상 제품입니다. -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LATS1 (Accession O95835), corresponding to amino acid residues C887–G937 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900134 |
Product Specific Information
Antibody detects endogenous levels of total LATS1/2.
Target Information
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with the cell cycle controller CDC2 kinase in early mitosis. It is phosphorylated in a cell-cycle dependent manner, remaining phosphorylated through metaphase. The N-terminal region binds CDC2 to form a complex with reduced H1 histone kinase activity, suggesting a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds to its own N-terminal region, indicating potential negative regulation through intramolecular binding. Biochemical and genetic evidence support its role as a tumor suppressor, demonstrated by knockout mice developing soft-tissue sarcomas and ovarian stromal cell tumors with high sensitivity to carcinogens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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