Thermo Fisher Scientific CD22/BL-CAM (B-Cell Marker) Monoclonal Antibody (BLCAM/1796)
CD22/BL-CAM 단클론 항체는 B세포 표지자로서 인간 CD22 단백질을 인식합니다. Western blot, ICC/IF, Flow cytometry, ELISA 등 다양한 응용에 사용 가능하며, 단백질 A/G로 정제된 무보존제 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | 2–4 µg/mL |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BLCAM/1796 |
| Immunogen | Recombinant fragment of human CD22 protein (around aa 52–178) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD22 (BL-CAM) is a type 1 integral membrane glycoprotein with a molecular weight of 130–140 kDa. It is expressed in the cytoplasm and cell membrane of B-lymphocytes and appears early in B-cell differentiation, similar to CD19.
CD22 membrane expression is limited to mature B cells (CD22+) and absent in plasma cells (CD22−), making it useful for phenotyping mature leukemias. It is strongly expressed in hairy cell leukemia, diffuse large B-cell lymphoma, and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
CD22 preferentially binds to α2,6-linked sialic acid, and its recognition site can be masked by cis interactions on the same cell surface. Ligand-induced tyrosine phosphorylation plays a role in regulating B-cell receptor signaling. CD22 functions both as a positive regulator through interaction with Src family tyrosine kinases and as an inhibitory receptor by recruiting cytoplasmic phosphatases via SH2 domains to modulate signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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