Thermo Fisher Scientific GNAT3 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total GNAT3 protein.

Target Information

Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction.
Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter.
GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors.
Functions also as lumenal sugar sensors in the gut to control the expression of the Na⁺-glucose transporter SGLT1 in response to dietary sugar, as well as the secretion of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
Thus, GNAT3 may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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