Thermo Fisher Scientific INSM1 Recombinant Rabbit Monoclonal Antibody (BLR272L)
INSM1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF에 적합합니다. Human 및 Mouse 시료에 반응하며, 고순도 정제 및 안정한 액상 형태로 제공됩니다. 신경내분비 종양 연구 및 INSM1 발현 분석에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR272L |
| Immunogen | Peptide representing a region between residue 50 and 100 of Human Insulinoma-associated protein 1 (INSM1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
Target Information
IA-1 (also known as INSM1) is an essential five zinc-finger transcription factor initially identified from an insulinoma cDNA library and expressed in the developing nervous system. IA-1 expression begins as early as E9.5 in mice in the forebrain, midbrain, hindbrain, spinal cord, retina, and olfactory bulb.
It functions as a transcriptional repressor and participates in several signaling pathways, including Notch, sonic hedgehog, and Ngn3 during pancreatic endocrine cell differentiation.
IA-1 is also expressed in multiple tumors, including most neuroendocrine tumors and nearly all small cell lung carcinomas, suggesting its potential as a cancer therapy target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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