Thermo Scientific™

Mass Spectrometry Cleavable Crosslinkers

Improve sensitivity of mass spectrometry detection of crosslinked proteins with MS-cleavable DSSO and DSBU heterotrifunctional crosslinkers.

Chemical crosslinking in combination with mass spectrometry is a powerful method to improve protein characterization and identification of protein-protein interactions. This method has been applied to recombinant and native protein complexes and, more recently, to whole cell lysates or intact unicellular organisms in efforts to identify protein-protein interactions on a global scale. The more recent enhancement of cleavability in DSSO and DSBU has improved MS compatibility and sensitivity of detection of crosslinked peptides and proteins.

사양

화학물질 반응성Amine-Amine

CleavableBy CID using MS

설명DSSO

분자량388.35

페길레이티드No

스페이서 암 길이10.3 Å

세포 투과성Yes

라벨링 방법Chemical Labeling

교차결합제 유형Homobifunctional

반응성 부분NHS Ester

스페이서Medium (10 to 30 Å)

형태Powder

수량10 x 1 mg

용해도DMF, DMSO

형식Standard, Single-use

수용성No

제품 유형Crosslinker

Unit SizeEach