Thermo Fisher Scientific MCL-1 Polyclonal Antibody
MCL-1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot, ICC/IF, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 액상 형태로 제공됩니다. 세포 생존 및 아폽토시스 연구에 활용됩니다.
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- PA5120604
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Thermo Fisher Scientific MCL-1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 50–150 of human MCL1 (NP_068779.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.293 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914176 |
Product Specific Information
- Positive test controls: Mouse spleen, Rat lung, Rat spleen
- Localization: Cytoplasm, Membrane, Mitochondrion, Nucleus, Single-pass membrane protein, Nucleoplasm
- Immunogen sequence:
GGEAGAVIGG SAGASPPSTL TPDSRRVARP PPIGAEVPDV TATPARLLFF APTRRAAPLE EMEAPAADAI MSPEEELDGY EPEPLGKRPA VLPLLELVGE S
Target Information
MCL1 (Myeloid cell leukemia-1) is a member of the Bcl-2 family, involved in cell differentiation and maintenance of viability. Isoform 1 inhibits apoptosis, while isoform 2 promotes it. MCL1 expression increases in response to DNA damage and is associated with mitochondrial localization. It interacts with pro-apoptotic Bcl-2 family members such as Bim or Bak to inhibit apoptosis. MCL1 is essential for embryogenesis and lymphocyte development, existing as two distinct isoforms, MCL1L and MCL1S.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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