Thermo Fisher Scientific TET2 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

TET2는 5-methylcytosine(5mC)을 5-hydroxymethylcytosine(5hmC)으로 전환하는 dioxygenase로, DNA 탈메틸화 과정에서 중요한 역할을 합니다. 또한 CpG-rich 전사 시작점에서 O-GlcNAc transferase(OGT)를 모집하여 히스톤 H2B GlcNAcylation을 촉진합니다.
TET2 유전자 변이는 Polycythemia vera 및 Myelodysplastic syndrome과 관련이 있습니다.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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