Thermo Fisher Scientific KLF10 Monoclonal Antibody (3F11)
KLF10 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western Blot 및 ELISA에 적합. 인간 유래 KLF10에 반응하며, PBS 용액 형태로 제공. TGF-β 관련 신호전달 연구 및 세포 성장 조절 연구에 활용 가능.
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Thermo Fisher Scientific KLF10 Monoclonal Antibody (3F11)
Applications and Tested Dilutions
- Western Blot (WB): 1–5 µg/mL
- ELISA: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F11 |
| Immunogen | KLF10 (AAH11538.1, 1–110 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEERMEMISE RPKESMYSWN KTAEKSDFEA VEALMSMSCS WKSDFKKYVE NRPVTPVSDL SEEENLLPGT PDFHTIPAFC LTPPYSPSDF EPSQVSNLMA PAPSTVHFKS
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It acts as a transcriptional repressor regulating cell growth and apoptosis. KLF10 binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta-mediated signaling to pancreatic epithelial cell growth regulation.
It is ubiquitously expressed in most tissues and may mediate up-regulation of TGFBI in VHL-deficient tumors. Overexpression of KLF10 is associated with renal clear cell carcinoma and other cancers.
KLF11, a related zinc finger transcription factor, binds SP1-like sequences in globin gene promoters, inhibiting cell growth and causing apoptosis. Defects in this gene are linked to maturity-onset diabetes of the young type 7 (MODY7).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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