Thermo Fisher Scientific Phospho-MAPK15 (Thr175, Tyr177) Polyclonal Antibody
Phospho-MAPK15 (Thr175, Tyr177) 폴리클로날 항체로, 인간 ERK8 인산화 부위에 특이적입니다. Western blot에서 1:500~1:1,000 희석으로 검증되었습니다. 세포 성장 및 분화 연구에 적합하며, 액상 형태로 -20°C에서 보관합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human ERK8 around the phosphorylation site of Thr175 and Tyr177 (A-V-TP-E-YP-V-A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555086 |
Target Information
The ERKs are a subfamily of the MAPKs implicated in cell growth and differentiation.
Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase.
ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha.
Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-38486_MAPK15_Q8TD08-1_Rabbit.svg
- PA5-38486_MAPK15_Q8TD08-1_Rabbit_PDP.jpeg
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