Thermo Fisher Scientific TBX3 Monoclonal Antibody (3A10)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
KENGTSDESS SEQAAFNCFA QASSPAASTV GTSNLKDLCP SEGESDAEAE SKEEHGPEAC DAAKISTTTS EEPCRDKGSP AVKAHLFAAE RPRDSGRLDK

Target Information

T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes.

Tbx3 protein acts as a transcriptional repressor binding canonical Brachychury sites and plays a role in the anterior/posterior axis formation of the tetrapod forelimb. It is required for normal mammary development and implicated in tumor development. Tbx3 expression increases during osteoblast differentiation and may regulate osteoblast cell numbers.

Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms. Subsets of human breast cancer cell lines overexpress TBX3. In vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.