Thermo Fisher Scientific Indoleamine 2 3-dioxygenase 1 Polyclonal Antibody, Biotin
IDO1 단백질을 표적하는 Biotin 결합 Rabbit Polyclonal 항체로, WB, ELISA, IP에 적합합니다. 친화 크로마토그래피로 정제되었으며, 다양한 종(마우스, 랫트)에 반응합니다. 연구용으로 사용되며, tryptophan 대사 및 면역조절 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 100–150 of human Indoleamine 2,3-dioxygenase 1 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of key molecules such as tryptophan, serotonin, and melatonin. This reaction initiates the formation of biologically active metabolites known as kynurenines. IDO1 is expressed in various tissues and immune cells, including macrophages and dendritic cells. Interferons (IFNs) induce IDO1 expression during inflammation, contributing to antimicrobial defense by degrading tryptophan and inhibiting the growth of pathogens. IDO1 also plays a crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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