Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI2D10), TrueMAB

Applications

Western Blot (WB)

• Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

T lymphocytes initiate cell-mediated immune responses upon stimulation by peptides bound to MHC molecules on antigen-presenting cells (APC).
Activated T cells express inhibitory receptors such as PD-1 (PDCD1), which interact with ligands PDL-1 and PDL-2 to suppress immune activation.
In the absence of danger signals (e.g., LPS), PD-1 signaling inhibits immune responses.
PD-1-deficient mice exhibit hyperactivated immune systems and autoimmune disorders.
Although its predicted molecular weight is known, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.