Thermo Fisher Scientific MASP2 Monoclonal Antibody (OTI7C4)
MASP2 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, 인간 시료에 반응하며 Western blot에 적합합니다. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 면역반응 연구 및 보체 경로 분석에 활용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7C4 |
| Immunogen | Human recombinant protein fragment (aa 445–686 of human MASP2, NP_006601) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitution: Add 100 µL distilled water to achieve ~1 mg/mL concentration.
- For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Mannose-binding lectin (MBL), also known as serum mannose-binding protein (MBP), initiates the lectin branch of the innate immune response by binding to pathogenic microorganisms and triggering complement fixation through its N-terminal collagen-like domain.
MBL interacts with MASP-1, MASP-2, and MASP-3 to activate the complement system. Mutations in MBL are linked to immunodeficiency due to impaired complement activation. MASP-3, an alternatively spliced product from the MASP-1 gene, may inhibit MASP-2 by competing for MBL binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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