Thermo Fisher Scientific PON1/Paraoxonase 1 Monoclonal Antibody (PON1/1351)
인간 PON1 단백질을 인식하는 단클론 항체로, IHC(P) 및 펩타이드 어레이에 사용 가능. 단백질 A/G로 정제된 액상 항체이며, 4°C에서 보관. 인간 간조직을 양성 대조로 활용 가능. 연구용으로만 사용.
- 카탈로그번호
- 5444-MSM1-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PON1/Paraoxonase 1 Monoclonal Antibody (PON1/1351)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PON1/1351 |
| Immunogen | Recombinant fragment (around aa1–200) of human PON1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human liver
- Cellular Location: Secreted; Extracellular space
Target Information
The paraoxonase (PON) gene family in humans has three members: PON1, PON2, and PON3, located on chromosome 7q21.3–22.1.
PON1 is synthesized primarily in the liver and secreted into plasma, where it associates with high-density lipoproteins (HDL).
It hydrolyzes active metabolites of several organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon) and nerve agents such as sarin, soman, and VX.
PON1 polymorphism has been linked to neurodegeneration and may serve as an independent risk factor for Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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